Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue

Yanming Li, Pingping Ren, Ashley Dawson, Hernan G. Vasquez, Waleed Ageedi, Chen Zhang, Wei Luo, Rui Chen, Yumei Li, Sangbae Kim, Hong S. Lu, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. LeMaire
Last updated on Jun 10, 2021
PDF DOI
Pinto Lab - Baker Heart and Diabetes Institute

Abstract

Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life-threatening complications. To improve our understanding of ATAA pathogenesis, this publication aimed to comprehensively characterize the cellular composition of the ascending aortic wall and to identify molecular alterations in each cell population of human ATAA tissues.

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disease_state
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gender
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source_name
156.45 G
54.31 Gb
Non-aneurysmal diseased control
female
GSM4704931
2020-08-02
GSM4704931
control_human ascending aortic tissue
205.82 G
71.74 Gb
Non-aneurysmal diseased control
male
GSM4704932
2020-08-03
GSM4704932
control_human ascending aortic tissue
107.57 G
38.88 Gb
Non-aneurysmal diseased control
female
GSM4704933
2020-08-02
GSM4704933
control_human ascending aortic tissue
169.86 G
60.84 Gb
Ascending thoracic aortic aneurysm (ATAA)
female
GSM4704934
2020-08-02
GSM4704934
ATAA_human ascending aortic tissue
157.94 G
57.16 Gb
Ascending thoracic aortic aneurysm (ATAA)
female
GSM4704935
2020-08-02
GSM4704935
ATAA_human ascending aortic tissue
184.15 G
66.46 Gb
Ascending thoracic aortic aneurysm (ATAA)
male
GSM4704936
2020-10-02
GSM4704936
ATAA_human ascending aortic tissue
157.86 G
57.16 Gb
Ascending thoracic aortic aneurysm (ATAA)
male
GSM4704937
2020-08-02
GSM4704937
ATAA_human ascending aortic tissue
247.08 G
84.05 Gb
Ascending thoracic aortic aneurysm (ATAA)
female
GSM4704938
2020-10-02
GSM4704938
ATAA_human ascending aortic tissue
138.66 G
48.93 Gb
Ascending thoracic aortic aneurysm (ATAA)
female
GSM4704939
2020-08-02
GSM4704939
ATAA_human ascending aortic tissue
186.69 G
65.58 Gb
Ascending thoracic aortic aneurysm (ATAA)
male
GSM4704940
2020-10-02
GSM4704940
ATAA_human ascending aortic tissue
100.04 G
36.82 Gb
Ascending thoracic aortic aneurysm (ATAA)
male
GSM4704941
2020-08-02
GSM4704941
ATAA_human ascending aortic tissue
human aorta